Relationship between Inhibitory Activity and Chemical Structure
نویسنده
چکیده
When it was found tha t 2,5-dimethylbenzimidazole inhibits the multiplication of influenza viruses (1-3), a systematic investigation of other alkyl derivatives of benzimidazole was undertaken. I t seemed probable tha t studies on the relationship between the chemical structure of such derivatives and their inhibitory act ivi ty relative to influenza virus multiplication would yield information of theoretical importance which might have practical usefulness. Also, it appeared possible that such studies could throw some light on problems regarding the nature and mechanism of biological specificity as exemplified in the process of virus reproduction.
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